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 Glycolic
acid ---Manufacture methods |
1. Chloroacetic acid hydrolysis method
chloroactic
acid reacts with sodium hydroxide (with methanol) and
produce hydroxy-acetic acid methyl ester, then after
hydrolysis, we can get glycolic acid.
The
reaction equation is as follows:
ClCH2COOH
+ NaOH  HOCH2COOH
+ NaCl
2.
Formaldehyde carbonylationl method
Under high
temperature, high pressure and acid catalyst, Formaldehyde,
carbon monoxide and water react and can produce glycolic
acid .
The
reaction equation is as follows:
3. Formaldehyde cyanidation method
Formaldehyde
reacts with hydrocyanic acid to produce glycolonitrile,
then undergo the hydrolysis to get glycolic acid. This
method features simple technics, stable operation and
good quality of products.
Microbe
catalysis method:
This
method is developed by Research Center of Shanghai Biochemical
Technology. In the microbial fermentation, special microorganism
containing nitrilase is produced, the nitrilase can
catalyze the glycolonitrile hydrolyse to yield glycolic
acid.
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